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One of the difficulties associated with growth hormone gene transfer is the necessity of modifying its tissue specific expression The present study used gh transgenic salmon as an experimental system to characterize the role of mstn in fast growing animals and to examine the relationship of mstn and gh expression. There is little value in transferring growth hormone.
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These data provide further examples of the complex pleiotropic effects arising from gh overexpression in transgenic salmon. In addition to growth enhancement, elevation of circulating gh in salmon by transgenesis is anticipated to have pronounced effects on other physiological processes. To examine the relative growth, endocrine, and gene expression effects of growth hormone (gh) transgenesis vs
The ocean pout (macrozoarces americanus) op5a antifreeze protein gene promoter has been used to generate a line of growth hormone (gh) transgenic atlantic salmon with greatly enhanced growth rates.
However, also hormone administration (gill et al., 1985) and transgenesis (du et al., 1992) have been explored in order to improve growth in atlantic salmon. For salmonids, du et al (1992) were the first to demonstrate a dramatic increase in growth of transgenic atlantic salmon (salmo salar) using a gene construct, opafpghc, which contains a chinook salmon gh1 cdna under the control of the ocean pout antifreeze promoter. Genetic alterations such as transgenesis can be useful, along with domestication and selective breeding, to improve aquaculture production efficiency and quality of end products
In particular, accelerated growth through growth hormone (gh) transgenesis has the potential to decrease production time and cost in a wide variety of.
